Anti-ganglioside antibodies and celiac disease

We describe our own experience on the prevalence of a wider range of anti-ganglioside antibodies and their clinical significance in CD patients. Using a commercially available ELISA kit (IMMCO Diagnostics, Buffalo, NY, USA), we studied anti-GM1, anti-GD1b, and anti-GQ1b serum IgG and IgM antibodies in 22 adult patients (median age 35, range: 19–56 years; three males, 19 females) with CD and neurological manifestations, including eight cases of idiopathic cerebellar ataxia, seven cases with epilepsy (without cerebral calcifications), two with multiple sclerosis, three with attention/memory impairment, and two with peripheral neuropathies. In all cases, diagnosis of CD was confirmed by endoscopic duodenal biopsy, revealing different grades of villous atrophy (from 3a to 3c, according to the modified Marsh classification). In all CD patients, intestinal villous atrophy was associated with a positivity for serological CD markers (anti-endomysial and/or anti-tissue transglutaminase antibodies) further supporting the diagnosis of CD. All available data, regarding CD diagnosis, diagnostic work-up, histopathology and treatment were obtained from the hospital digital database

Sciatic neuropathy in an acromegalic cat without concurrent diabetes mellitus

Case summary: A 17-year-old neutered male European Shorthair cat was presented owing to an inability to jump and respiratory stridor. The owner did not report any other clinical signs. On physical examination, the main findings were plantigrade stance, broad facial features and inspiratory stridor. Neurological examination revealed posterior paraparesis, hypotonia and right hindlimb muscle atrophy. Laboratory findings were unremarkable and glycaemia was normal. Serum insulin-like growth factor 1 concentration was elevated (>1000 ng/ml). A total body CT scan showed an enlarged pituitary gland, thickening of the nasal turbinates and an L7–S1 right foraminal stenosis. Electrodiagnostic testing confirmed the presence of a neuropathy affecting both sciatic nerves. The cat was treated with gabapentin only and was still alive and euglycaemic 16 months after the diagnosis. Relevance and novel information: This case describes for the first time sciatic neuropathy, an occasional complication of acromegaly in people, as a possible clinical presentation in acromegalic cats without concurrent diabetes mellitus

Pengaruh Etika, Pendidikan Dan Pengalaman Terhadap Profesionalisme Auditor Internal Dengan Motivasi Sebagai Variabel Intervening (Studi Pada Inspektorat Wilayah Kabupaten Kampar Provinsi Riau)

This study was aimed to examine the direct effect of Ethics, Education, Experiance and motivation, and also significant effect of Ethics, Education, and Experiance On The Auditor's Internal Professionalism with motivation as intervening variable. Collecting data of this study using a questionnaire submitted to 43 auditors who work at Inspektorat Jenderal Kampar Regency Riau Province Representation. From questionnaires distributed 43 questionnaires (93%) were completed and can be processed. Data analysis for hypothesis test was done with Partial Least Square (PLS). Parameter Significant tested by comparing the value tstatistic with ttable, where the value tstatistik>ttabel at 0,0=2,02 confidence level, its meaning there significant influence between independent variabel with dependent variabel. Result of this study give evidence that ethics with significant 3,605, education with significant 2,318, experiance with significant 2,311, and motivation with significant 2,733 have effect on Auditor's internal professionalism. Ethics with significant 6,780 and education with significant 6,896 also have effect on motivation. Ethics with significant 2,512 and also education with significant 2,518 have effect on auditor's internal professionalism through motivation. But, experiance have no significant effect on motivation and also have no significant on auditor's internal professionalism through motivation